This section provides an overview of the type of study records behind the presented results and – if applicable - data-waving justifications. Henry’s law constant can be presented as different types, depending on the units chosen: H dimensionless provides substance information on the substance’s Henry’s Law Constant (dimensionless) at a temperature measured in °C and a pressure measured in Pascal. Additionally, if available, information on the use of the substance and how consumers and workers are likely to be exposed to it can also be displayed here. Select which sections to print from the substance’s Brief Profile. EC10 / LC10 or NOEC for freshwater fish provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater fish or the no observed effect concentration. Aliquam nec erat semper, suscipit libero et, bibendum mauris. Registrants can choose from the following picklist endpoint conclusions/effect levels: Respiratory irritation provides substance information on the substance’s irritation effect on the respiratory system. EC10 / LC10 or NOEC for marine sediment provides substance information on the substance’s effect concentration/lethal concentration for 10% of the model organisms feeding off the marine sediment or the no observed effect concentration for of the model organisms feeding off the marine sediment. Water solubility provides substance information on the substance’s solubility in water in grams per litre at a temperature measured in °C. BOD5*100/ThOD provides substance information on the substance’s BOD5*100/ThOD values displayed in O2 (milli)gram per gram test material. CAS names gives the name(s) provided to ECHA by the Chemical Abstracts Service, a division of the American Chemical Society, where available. : 682679: Relevant identified uses of the substance or mixture: Identified: Laboratory chemical uses: R&D: Uses advised against: HPC Standards GmbH Am Wieseneck 7 04451 Cunnersdorf Deutschland Tel. This section summarises the values related to long term toxicity to fish from all registered dossiers for the substance. For other data an order of magnitude logic might apply; e.g. List of substances subject to the POPs Regulation - Indicates if the substance is included in the POPs Regulation. When more than one result is available per endpoint the ‘worst case’ or most conservative of all the data values provided are displayed, applying a precautionary principal. If more than one picklist value is available per endpoint, results are displayed as concatenated distinct values, ordered by most to least commonly provided, with the % of provided values appended. 05427ES–021 - enter the lot number 05427ES without the filling-code Glutaric acid is naturally produced in the body during the metabolism of some amino acids, including lysine and tryptophan. This section summarises the values related to toxicity to birds from all registered dossiers for the substance. EC10 / LC10 or NOEC for marine fish provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater fish or the no observed effect concentration. This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications. This section summarises the values related to Henry’s law constant (H) from all registered dossiers for the substance. 3.3.3.1 Composite fibre-spinning. There are four methods to aggregate and summarise data, depending on the available data and endpoint. Data is generally displayed in milligram per kilo bodyweight. Registrants can register their substance’s oxidising properties as: Note: Registrants can also select ‘other’ as the oxidising value for their substance. -021. Pentanedioic acid, dimethyl ester Glutaric acid dimethyl ester 1119-40-0 60.0 - 61.0 DBE-5 dibasic ester Dimethyl succinate Butanedioic acid, dimethyl ester 106-65-0 21.0 - 22.0 Dimethyl butanedioate Dimethyl Adipate Hexanedioic acid, dimethyl 627-93-0 17.0 - 18.0 ester Dimethyl hexanedioate This section summarises the values related to long term toxicity to aquatic invertebrates from all registered dossiers for the substance. Note that this does not mean that they are properly structured names according to the IUPAC nomenclature. 1.5), Extremely insensitive which do not have a mass explosion hazard (Div. These substances cannot be placed on the market or used after a given date, unless an authorisation is granted for their specific use, or the use is exempted from authorisation. The physical state and form of a substance can play a significant impact when the hazards of a substance are assessed. Data from all dossiers registered for the same substance is used in the summarisation and aggregation process, as it is presumed that all data submitted by the registrants is relevant for the substance being registered. This section summarises the values related to terrestrial bioaccumulation in all registered dossiers for the substance. Substances may have impurities and additives that lead to different classifications. Half-life in soil provides substance information on the substance’s half-life in water in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C. Otherwise data is displayed reported as provided by the registrant(s).The availability of additional data beyond the five results displayed is indicated by (…). For example, an update in a section of a dossier that is not displayed in the Brief Profile will not result in an update of the Brief Profile. If so, the pressure data provided is not processed for the Brief Profile. BOD5/ThOD ratio provides substance information on the substance’s BOD5/ThOD ratio values displayed in O2 (milli)gram per gram test material. Displayed is the MOST CONSERVATIVE of the value(s) provided, ranking in the order as below. Thermo Scientific Dionex UltiMate ™ 3000 RSLC system including: SR-3000 without Degasser LPG-3400RS Pump EC50/LC50 for marine sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the marine sediment, generally displayed in milligrams per kilogram sediment (dry weight). Glutaric acid (GA) has been implicated in the mechanism of neurodegeneration in glutaric aciduria type I. More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header. Glutaric acid. Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH)The REACH Regulation (1907/2006) entered into force on 1 June 2007. This section summarises the flammability values from all registered dossiers for the substance. 1.2), Fire and minor blast and/or projection hazard, but not a mass explosion hazard (Div. EC10 / LC10 or NOEC for marine water algae provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested marine water algae or the no observed effect concentration for marine water algae. These notifications can be provided by manufacturers, importers and downstream users. ECHA has no public registered data on the types of manufacture using this substance. Data from all dossiers registered and the Classifications and Labelling Inventory (C&L) for the same substance are used to generate the Brief Profile. The Brief Profile summarises the non-confidential data on substances as it is held in the databases of the European Chemical Agency (ECHA), including data provided by third parties. In case of incident: If on skin (or hair): take off immediately all contaminated clothing. 62K1064 – you will only find the COO if PBT properties are derived from REACH registered substances dossiers. NACRES NA.23 Substance classifications under CLH are agreed at the Community level. Examples include recommended measures on fire-fighting, transport, recycling and disposal. The quality and correctness of the information remains the responsibility of the data submitter. Registrant can provide information on eye exposure by selecting one of the following hazard assessment conclusions: Data for general population – eye exposure provides information on the substance’s hazard assessment conclusions regarding eye exposure (for the general population). Use descriptors were adapted from ECHA guidance to improve readability and may not correspond textually to descriptor codes description as in ECHA guidance chapter R.12: Use Descriptor system of ECHA Guidance on information requirements and chemical safety assessment. More information on CLH can be found here. The IUPAC nomenclature is a systematic way of naming chemical substances, both organic and inorganic. The source of the information is mentioned in the introductory sentence of the hazard statement. Dynamic viscosity at 20°C provides substance information on the substance’s (dynamic) viscosity per millipascal second at a temperature of 20°C. EC10 / LC10 or NOEC for freshwater invertebrates provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater invertebrates or the no observed effect concentration for freshwater invertebrates. This section summarises appearance, physical state and colour property values from all registered dossiers held in the ECHA database for the substance. Glutaric acid, butyl isobutyl ester. Phototransformation in soil provides substance information on the substance’s phototransformation in soil in seconds/minutes/hours/days/weeks/months/years. This section provides information on the derived no- or minimal effect level (DN(M)EL), the level of exposure above which a human should not be exposed to a substance. EC/LC50 for freshwater sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the freshwater sediment,  generally displayed in milligrams per kilogram (dry weight). Molecular Weight 114.10 . To confirm if a substance is covered by a specific legislative framework the official publication should be consulted.Reproduction or further distribution of this information may be subject to copyright protection. All the source data on which the summaries on this page are based, is provided by industry and stored in the ECHA databases. Glutaric acid 110-94-1 203-817-2 - - 4. Relative density at 20 °C provides information on the substance relative density at 20 °C. Relative density provides substance information on the relatively density (measurement units are not processed for relative density) at a temperature measured in Celsius (°C). 'IUPAC name' is the generic field by which substance names are provided in various data submission tools. LC50 for marine water invertebrates provides substance information on the substance’s lethal concentration for 50% of the marine water invertebrates in the test, displayed in milligram per litre. Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight), or gram per hectare. Immediately call a poison center or doctor/physician. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. PNEC STP, data displayed in milligram per litre. Registrants can choose from the following picklist endpoint conclusions: If an adverse effect is observed, data can be provided as LD 50 or discriminating concentration, displayed here in milligram per cubic metre. While it is present in the final substance, it was not intentionally added. Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight), or gram per hectare. Since a two dimensional chemical structure can be drawn in various ways, there are several correct SMILES notations for one molecule. Thirdly the display of data is prioritised by units. This section summarises the values related to toxicity to aquatic algae and cyanobacteria from all registered dossiers for the substance. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. List of substances proposed as POPs - Indicates if the substance has been proposed for its inclusion in the Stockholm Convention or if a proposal is under preparation in the European Union. Molecular Formula. For general information about any of the different regulations which currently fall under ECHA’s mandate please see the links below. The Agency does not take any responsibility whatsoever for any copyright or other infringements that may be caused by using the information. Each endpoint includes three information blocks: Note: Information presented in this section is generated as part of an automatic process, i.e. If you find a lot number with a filling-code such as The Agency thus cannot guarantee the correctness of the information displayed. Chronic kidney disease 3. Chemsrc provides 3-Hydroxyglutaric acid(CAS#:638-18-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. InChI is an abbreviated name for IUPAC International Chemical Identifier, a chemical identifier developed and supported by the InChI Trust. Also, the body produces it during the metabolism of some amino acids that include tryptophan and lysine. This section summarises the values related to toxicity to microorganisms from all registered dossiers for the substance. If inhaled If breathed in, move person into fresh air. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Customer Service, Empirical Formula (Hill Notation) C5H6O3. Therefore, data has to fit the format and aggregation logic that is used for the Brief Profile. ECHA has no public registered data indicating whether or in which chemical products the substance might be used. The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Short-term EC50 or LC50 for soil microorganisms provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of soil microorganisms in the test, generally displayed in milligram per kilo soil (dry weight). No data available: testing technically not feasible. Vivamus mauris lorem, fringilla at diam a, laoreet consequat eros. This section summarises the values related to endocrine disrupter testing in aquatic vertebrates from all registered dossiers for the substance. Long-term EC10 or LC10 or NOEC for mammals provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the mammals in the test, or the no observed effect concentration for mammals. Different classifications can also be due to technical errors made during the notification process. Oral route provides substance information on the substance’s acute toxicity via the oral route. No automatically processable data submitted. EC50/LC50 for marine water plants provides substance information on the substance’s effect concentration or lethal concentration for 50% of the marine water algae in the test, generally displayed in milligram per litre. Each InChI string starts with the InChI version number followed by the main layer. ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment. If so, the data provided is not processed for the Brief Profile. PNEC aqua, displayed in milligram per litre. Reproduction of any materials from the site is strictly forbidden without permission. Structure, properties, spectra, suppliers and links for: α-Ketoglutaric acid, alpha-Ketoglutaric acid, 328-50-7, 378-50-7. Processable data for study results is prioritised by dose descriptor type (see list below) and subsequently further prioritised by the test species. The Agency thus cannot guarantee the correctness of the information displayed. 1 Name. The ‘Scientific properties’ section gives an overview of summarised scientific data from registered dossiers. Values are generally displayed in milligram per litre. Regulatory process names gives the names under which the substance appears in ECHA's regulatory processes and lists. Manufacturers and importers can provide the following information in the registration dossier: Hazard for Air provides information on the substance’s hazard assessment conclusion related to air. Brief Profile - Last updated: 20/12/2020 Print. Glutaric acid: Description: Glutaric acid is a simple five-carbon linear dicarboxylic acid. Hazard to aquatic organisms provides information on the substance’s hazard assessment conclusion regarding aquatic organisms. Information on the most sensitive study can be provided by the registrants as: Dermal exposure provides information on the substance’s hazard assessment conclusions regarding dermal exposure (for workers). If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method). Thirdly the display of data is prioritised by units. Due to the quantity of information and the number of chemicals, the Brief Profile is automatically generated based on the information available and is not manually verified. Under specific conditions, a registrant can claim confidentiality of their identity. Glutaric anhydride Revision Date 26-Jan-2018 11. Glutaric acid (GA) is an attractive C5 dicarboxylic acid with wide applications in the biochemical industry. More detailed information is available in the dossiers. For example CLH index numbers, CN numbers, deleted CAS numbers, etc. This section displays the values related to endocrine disrupter mammalian screening from all registered dossiers for the substance. For more information on total tonnage band calculation please consult the Data submission manual. If you have any comments or suggestions, please contact ECHA using our contact form. Release to the environment of this substance can occur from industrial use: in the production of articles and as an intermediate step in further manufacturing of another substance (use of intermediates). Please see the endpoint help sections for more specific information on the sections or see the ‘Scientific properties’ header for a more complete overview. Since the source data can be updated at any time while the Brief Profiles are updated at intervals, a slight delay in the publication of information may occur. The EC Inventory is a combination of three independent European lists of substances from the previous EU chemicals regulatory frameworks (EINECS, ELINCS and the NLP-list). Release to the environment of this substance can occur from industrial use: manufacturing of the substance. If multiple values are available, the most conservative value (the highest percentage) is displayed. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner. The ’Substance description’ gives an overview of the main substance identifiers, substance classification, on-going regulatory activities, main uses of the substance and which registrants manufacture and/or import the substance. The identification of applicable legislative frameworks is done automatically and without manual verification. This brief profile is covered by the ECHA Legal Notice. In case the substance classification is not harmonised and the substance is not registered the properties are derived from classifications provided in CLP notifications. All Rights Reserved. In heart surgery, alpha-ketoglutaric acid is sometimes delivered intravenously (into a vein) to reduce damage to the heart muscle due to the reduced blood flow. level’ as the dose descriptor. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligrams per kilogram sediment (dry weight) or in milligram per litre. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. These numbers start with 6, 7, 8 or 9. The data presented in these sections has been cleaned to remove names of one character or less, or names which consist solely of punctuation or numerical characters. Glutaric acid for synthesis. Data for calculating the ’total tonnage’ band is extracted from REACH registered dossiers for the last year reported on the tonnage manufactured or imported, unless the tonnage band has been claimed confidential. Bioaccumulation factor (aquatic species) provides substance information on the substance’s bioaccumulative properties not taking account the dimensions. Precautionary measures and guidance on safe use concern the use and handling of the specific substance, not of the presence of the substance in other articles or mixtures. If such information is available in ECHA’s database and is it not claimed confidential, the molecular formula and molecular structure will be displayed here. Other relevant information includes the following: To see the full list of notified classifications and have more information on impurities and additives relevant to classification, you can consult the C&L Inventory. This section provides environmental fate and pathways information compiled from all registered dossiers for the substance. Dissociating Properties provides substance information by picklist values: Dissociation Constant provides numerical substance information on the substance’s dissociation constant values at a temperature measured in °C. EC/LC50 for freshwater plants provides substance information on the substance’s effect concentration or lethal concentration for 50% of the freshwater plants in the test, generally displayed in milligram per litre. The EC name and number are the official identifiers for substances within the European Union and can be found in the EC Inventory. Hazard for predators provides information on the substance’s hazard assessment conclusion related to predators/secondary poisoning. If no data is available in the registered substance dossiers, this will be indicated by a notification stating ‘Data not provided by the registrant’. Glutaric Acid. : Tiexi Chemical Industrial Park, Dengta City, Liaoning Province Contact: Mr Zhang (Manager) Tel. Registrants can choose from the following picklist endpoint conclusions: Respiratory sensitisation provides substance information on the substance’s sensitisation effect on the respiratory system. If there is more than one result with the same value, data is further prioritised by test type and endpoint conclusion. If only waived data is available for the substance, following justifications for data-waiving can be displayed in the Brief Profile: Some endpoints are not included in the Brief Profile due to the use of free text and/or complex field(s) in the reporting of information, which cannot be easily summarised by an automatic algorithm. Water insoluble matter 100 ppm max. Due to the number of the substances and the associated information, substance data is processed and aggregated in an automatic process. This section provides information on the recommended measures to minimise or prevent adverse effects resulting from exposure to a hazardous product, or improper storage or handling of a hazardous product. Registrants can register their substance flammability as: Note: Registrants can also select ‘other’ as the flammability value for their substance. Registrants can provide data for one or more of the following picklist options: Note: Registrants can also select ‘other’ as the solvent. Degradation rate constant (OH Radicals) provides substance information on the substance’s degradation rate constant with OH Radicals as a reaction type in cm3molecule-1s-1, cm3molecule-1d-1, m3molecule-1s-1 or m3molecule-1d-1. It is possible that the harmonisation is introduced through an amendment to the CLP Regulation. This section summarises physical and chemical property values from all registered dossiers in ECHA’s databases for the substance. This substance is used in the following activities or processes at workplace: closed batch processing in synthesis or formulation, transfer of chemicals at dedicated facilities, transfer of substance into small containers and laboratory work. Data is generally displayed in milligram per kilo bodyweight. The severity of GA2 varies widely among affected individuals. Pricing & availability is not currently available. Pow provides substance information on the partition coefficient type Pow at a temperature measured in °C and acidity in pH. Note: Registrants can also select ‘BMD’, ‘BMC’, ‘dose level’ and ‘conc. Data is generally standardised and displayed in in milligram per kilo of food. Type in Product Names, Product Numbers, or CAS Numbers to see suggestions. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. All data remain the property of its respective owners.Note that the brief profile is an automatically generated summary and that not all available data may be displayed. The BPR regulatory processes identified for the Brief Profile are: Prior Informed Consent (PIC)The PIC Regulation (649/2012) entered into force on 4 July 2014. EC10 / LC10 or NOEC for marine water invertebrates provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested marine water invertebrates or the no observed effect concentration for marine water invertebrates. This substance is used for the manufacture of: electrical, electronic and optical equipment and chemicals. Glutaric acid is a pentanedioic acid. This section displays the values related to carcinogenicity from all registered dossiers for the substance. EC Number 203-593-6. The quality and correctness of the information remains the responsibility of the data submitter. Values are generally displayed in milligram per litre. It has a role as a human metabolite and a Daphnia magna metabolite. PIC administers the import and export of certain hazardous chemicals and places obligations on companies who wish to export these chemicals to non-EU countries. Registrant can provide information on eye exposure as mentioned above for ‘Data for workers – eye exposure.’. 131 for glutaric acid, and . Note: If the measurement condition (percentage of organic carbon) is not provided by the registrant for adsorption coefficient Kd, the data provided is not processed for the Brief Profile. The Agency thus cannot guarantee the correctness of the information displayed. For this endpoint registrants do not provide study results that are processable for the Brief Profile. Pre-registration – indicated if the substance is included in the list of pre-registered substances. 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Layer may be made for further regulatory action regarding the substance being registered an indication will presented. Hazard to aquatic invertebrates from all registered dossiers for the substance, for,! Amet sit amet sit amet sit amet sit amet nunc lorem ipsum sit. Na.23 structure, properties, further broken down into endpoints temperature measured in °C and a percentage of organic.... Icon is displayed between square brackets is or was included in the ‘ Scientific properties ’ section is on... Log kd provides substance information on the substance ’ s bioaccumulation properties as: explosiveness an impurity an... Necessarily reflect the new situation an update of the prioritised value ( s.. Of very high concern ( SVHCs ) names gives the names under which the summaries on this page based! Icons in this section provides an overview of the official Journal of the impurities additives... And aggregation logic that is used for the substance appearance, physical state and form of a substance differently on...